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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-140-5p
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples; RB cell lines
Methods qRT-PCR, Western blot, CCK-8 assay, Edu staining, colony formation assay, flow cytometry, wound-healing assay and transwell assay, immunofluorescence, luciferase reporter assay
Expression pattern down-regulated
Functional description Overexpression of miR-140-5p inhibited proliferation, migration, and invasion of RB cells. miR-140-5p might negatively regulate the transcriptional activities of CEMIP and CADM3 by targeting their 3'-UTR.
PubMed ID 29808799
Year 2018
Title miR-140-5p suppresses retinoblastoma cell proliferation, migration, and invasion by targeting CEMIP and CADM3.
Drug-related ncRNA NO

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